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Tests To Help With Breast Cancer Treatment Decisions

Herzlichen Dank an The Breast Cancer Authority!

When you’ve just received a diagnosis of breast cancer, you are faced with many different treatment options. Your mind is in a whirl with fear, confusion, and disbelief. While none of these feelings help decision making, there are some tests that can help: Oncotype DX and Mammaprint. 

These tests are genomic tests that analyze the activity of specific genes in the breast tumor. They can help you determine if your risk of breast cancer coming back is high or low, which can help you in making a decision about whether to have chemotherapy, radiation, or other therapies to reduce risk after surgery.

There are two main types of tests – Oncotype DX and Mammaprint.

Oncotype Dx has two tests for breast cancer – one for Ductal Carcinoma in situ (DCIS) – Oncotype DX DCIS and one for invasive breast cancer – Oncotype DX.  Mammaprint has one test for invasive breast cancer. Let’s look at these in greater detail.

What are genomic tests?

Genomic tests look at specific genes in your individual tumor and try to determine what is driving its growth. This is different from genetic tests which look at your inherited risk or predisposition for cancer. Genomic tests provide information that can help tailor your treatment plan to you as an individual. They are a type of personalized medicine. This is really important, because not all breast cancers are the same and, in fact, some breast cancers might have more in common with a prostate cancer than they do with another type of breast cancer. One size treatment definitely does not fit all.

Oncotype DX DCIS

This test is only for people diagnosed with DCIS or, as it is often called, “stage zero” breast cancer. In addition to general information such as tumor size, margins, and grade, Oncotype DX DCIS helps determine the likelihood of DCIS recurring or invasive breast cancer occurring within the next 10 years.

It examines a sample of the tumor tissue that has already been removed during the lumpectomy for DCIS. By looking at the expression of 21 different genes in the tumor, it provides a DCIS score of between 0-100. The lower the score, the lower the risk of recurrence. Two scores are given, one to determine the risk of recurrence of DCIS and another for the risk of occurrence of an invasive breast cancer.

Knowing the DCIS score can help you decide whether to have radiation treatment  following the lumpectomy. If your risk of recurrence is low, then maybe you can spare yourself further treatment and the possible side effects that go with it.

To be eligible for Oncotype DX DCIS, you need to have recently been diagnosed with DCIS and had lumpectomy surgery. The decision should be made in discussion with your doctor/oncologist.

In the US, insurance might cover the cost of this test; the testing company will help you determine if this is the case and provide information to your insurers, as necessary. In the UK, these tests can be conducted under the NHS or privately.

Many oncologists are now familiar with these tests for invasive breast cancer; sadly, the Oncotype DX DCIS test does not appear to be known by all oncologists, so it’s good for you to be proactive and start the discussion. Here is a link to the validation work done on the test that you can forward to your oncologist, and further links are given at the bottom of this post:

Clinical validation of oncotype DX DCIS

I definitely think it is worth having a discussion with your oncologist, sharing the references as necessary, and if you don’t get anywhere with the oncologist, talk to your family doctor or surgeon.

Oncotype DX and Mammaprint

Both Oncotype DX and Mammaprint are genomic tests suitable for early stage invasive breast cancer. They both predict the benefit of chemotherapy or other types of treatment, as well as the likelihood of 10 year recurrence.

They are similar tests but have some differences, as outlined below:

Comparison of oncotype DX and mammaprint for invasive breast cancer

Looking at this table can help determine if you are eligible for either of these tests.

As with Oncotype DX DCIS, some insurance companies in the US will pay for these tests whereas some don’t include them in coverage. Both testing companies offer financial assistance or guidance, so it’s worth calling them to discuss if you are interested and want to check coverage. In the UK, these tests can be conducted under the NHS or privately.

These tests are important because some of the cancer treatments, like chemotherapy, can have many side effects and are hard to get through. If there is little to no benefit in these treatments for you as an individual, then these genomic tests give you the confidence to not have a treatment that has greater potential for risk than for benefit.

Obviously the decision of further treatment is based on more than just these results. It involves detailed discussion with your oncologist, but also personal consideration of what you want and how you feel. Remember, you can take your time over treatment decisions. You might feel rushed, but take adequate time until you feel comfortable that you are making the right personal decision. These tests can go a long way in giving you confidence in your decision, but it is still a personal choice that needs to be right for you as an individual based on your mind and spirit, as well as your body.

Here are links to each of these three tests for more information

Patient information on Oncotype DX DCIS

Oncologist information on Oncotype DX DCIS

Patient information on Oncotype DX

Oncologist information on Oncotype DX

Patient information on Mammaprint

Oncologist information on Mammaprint

Let me know if you’ve had any of these tests and how they helped you.

Ruth BaillieRuth Baillie is originally from the UK and now lives most of the year in Northern California. She holds two Master’s degrees, one in Personalized Nutrition (distinction), and another in Health Psychology. She is a Registered Nutritional Therapist, Certified Professional Cancer Coach, and Cancer Guide, and has undertaken considerable post-graduate studies in integrative naturopathic oncology. She is the author of “Choices in mind-body medicine for cancer patients in Sonoma County, California” and her research has been published in peer-reviewed journals.

 

Tests To Help With Breast Cancer Treatment Decisions

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3 Kommentare

Yoga , Breast Cancer , good stuff

http://breastcanceryogablog.com/2015/01/22/rochelle-roll-back-yoga-pose-for-breast-cancer/

This is terrific ! Many thanks to your team. Keep up the fantastic work!

 

Rochelle Roll Back Yoga Pose For Breast Cancer

Rochelle Roll Back Yoga Pose For Breast CancerAuthor: Diana Ross, E-RYT 500, Posted By: Breast Cancer Yoga Staff.

In Breast Cancer Yoga, the use of props are essential for a person to feel safe, supported and nurtured. These specific, reclined, supported, yoga poses combined with deep breaths are intended to support recovery from breast cancer and assist in managing lymphedema and cancer-related fatigue. In our book, “Restorative Yoga For Breast Cancer Recovery” everyone will learn the importance of elongating the spine while opening the chest region using props for support . The mild inversions are used to create an anti-gravitational force in the pose which will renew energy, promote positive thoughts and enhance self esteem.

“Importantly, when props are used correctly, they allow the body to come into a natural and balanced state of alignment. When the body is aligned, the mind feels balanced as well. Once the body and the mind unite, the breath too becomes aligned and brings a deeper, internal state of peace.”

Diana Ross

Benefits:

  • Reduces respiratory & heart rates
  • Increases cervical and axillary lymphatic drainage
  • Aids flexibility of rib cage and thoracic spine and expands pectoral muscles
  • Relaxes the muscles of the chest, allowing blood to flow freely to the heart and lungs
  • Massages the thymus gland which stimulates the immune function
  • Boosts the nervous system, building heat and stimulating metabolism
  • Facilitates lymphatic drainage of breasts
  • Stretches groin, quadriceps and hip flexors
  • Promotes deep breathing by widening the chest
  • Facilitates an inner quiet and calmness

Instructions:

    1. Begin seated with one or two bolsters/blocks behind. Bring right knee out to side with right foot resting on left inner knee (adjust hips to be equal.) Place top of left foot down to stretch ankle.
    2. Lengthen spine, recline back, rest elbows to bolster first. Stay until a release is felt in the thigh muscles.
    3. To expand the chest, drape your back over the bolsters and place head on block/bolster or where it feels good. The arms can go out to “T” position in between bolsters.
    4. If you wish to go even deeper you can remove second bolster/block and release crown of head to earth, and stretch arms over head, elbows soft.
    5. Stay in pose for 5 minutes or longer if it feels amazing.
    6. When finished, come back up, extend both legs forward.
    7. Place cylinder bolster on lap and drape torso over bolster in ROCHELLE ROLL FORWARD.
    8. When done – INHALE, return to STAFF POSE and enjoy ANKLE ROTATIONS.

To experience the benefits of yoga for breast cancer, it is essential that you begin with simple, gentle yoga movements. You should also consult a doctor before you begin practicing yoga. It is also necessary that you follow a yogic diet that consists of a mainly vegetarian diet to enhance the benefits of yoga.

Diana RossAbout Diana Ross:  E-RYT 500 restorative yoga teacher, survivor that cares and founder of Breast Cancer Yoga. Diana is making a difference with Breast Cancer Yogatherapeutic products designed to support you emotionally and physically during breast cancer . We want to give you the attention and personal service you need so please email us at info@breastcanceryoga.com if you have questions.