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Lymphatic Vessels Traced to Overlooked Embryonic Source

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GEN News Highlights

May 21, 2015

Lymphatic Vessels Traced to Overlooked Embryonic Source

  • Scrutiny of fluorescently labeled zebrafish embryo blood vessels revealed that angioblasts tucked within the cardinal vein give rise to lymphatic vessels. [Weizmann Institute of Science]

    A durable Roman proverb—“It would be easier to find the source of the Nile”—may have occurred to scientists seeking the origins of the lymphatic system. Not only were these origins as obscure as a shifting maze of marshy channels, they gave rise to long-running disputes. Close to a century ago, two competing proposals for the lymphatic system’s origin emerged, and although one gained broad acceptance, the other was never entirely discounted.

    Some scientists claimed that the lymphatic system was derived from specialized stem cells called angioblasts, whereas others argued that it originated by the differentiation of preexisting embryonic veins. The latter model ultimately became the accepted view.

    New research, however, suggests that there is truth in both views, which may seem less surprising one likens the difficulty in delineating fluid flows to the difficulty in following the subtle differentiation events by which multipotent embryonic cells acquire recognizable cellular identities. These differentiation events attracted the attention of a group of scientists at the Weizmann Institute, who were as intrepid, in their own way, as the Victorian-era explorers who sought the Nile’s origins.

    The Weizmann scientists, led by Karina Yaniv, Ph.D., gave an account of their work May 20 in Nature, where they described the lay of the land as follows: “Multipotent progenitors undergo cell-fate restriction in response to cues from the microenvironment, the nature of which is poorly understood.”

    Undaunted, Dr. Yaniv and colleagues not only determined the source of lymphatic cells, they used their newfound knowledge to grow, for the first time, lymphatic cells in the laboratory. As for the source, that is made clear in the title of their Nature paper: “Lymphatic vessels arise from specialized angioblasts within a venous niche.”

    “Here we show that in zebrafish, lymphatic progenitors arise from a previously uncharacterized niche of specialized angioblasts within the cardinal vein, which also generates arterial and venous fates,” the article’s authors wrote. “We further identify Wnt5b as a novel lymphatic inductive signal and show that it also promotes the ‘angioblast-to-lymphatic’ transition in human embryonic stem cells, suggesting that this process is evolutionarily conserved.”

    When Weizman postdoctoral fellow Yogev Sela added WNT5B to human embryonic stem cells, these cells indeed differentiated into lymphatic cells—the first time such cells had been grown in the lab. „We started out by imaging zebrafish, and ended up finding a factor that makes it possible to create lymphatic cells,“ said Dr. Yaniv. „That’s the beauty of research in developmental biology: The embryo holds the answers, and all we have to do is watch and learn.“

    Aside from the feat of answering the longstanding question of how the lymph system arises, understanding how it forms and develops can provide important insights into disease, from metastasis to the abnormal accumulation of lymph fluids, particularly in the wake of surgery to remove cancerous tumors.

    http://www.genengnews.com/gen-news-highlights/lymphatic-vessels-traced-to-overlooked-embryonic-source/81251307/

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Autor: monica boersch

Vor ein paar Jahre bin ich an Krebs erkrankt, bedingt durch meine Wertheim OP, Bestrahlung und Afterloading habe ich Lymphödeme bekommen, für mich sehr überraschend da ein paar Jahre dazwischen lagen, ich wusste das etwas nicht stimmt aber leider konnten unzählige Ärzte nicht helfen. Hier ist es auch so, wie in viele viele andere Länder auch, dass Lymphatische Erkrankungen erstens nicht wirklich ernst genommen werden und zweitens das kaum ein Arzt darüber Bescheid weiß, wie den auch, wenn in den Lehrbüchern so gut wie NICHTS steht. Mein Bestreben ist alles zu tun was in meiner Macht steht um dafür zu sorgen das jeder der betroffen ist weiß was er/ sie tun kann um sein Leben wieder so gestalten zu können wie er/sie das möchte. . Ich suche und suche immer weiter nach alternativ Möglichkeiten um meinen Leben so normal wie möglich zu gestalten. Die Empfehlungen die ich gebe sind bei mir durchaus wirksam und ich erziele gute Erfolge und behalte meine Lebensqualität. Mein Blog ist kein Ersatz für eine Ärztliche Betreuung und ich empfehle jeden mit seinem Arzt über Therapie Möglichkeiten etc. zu sprechen. Ich kann nur anregen und durch meine eigene, persönliche Erfahrung eventuell einen weg aufzeigen. Seit 2009 beschäftige ich mich weit über das übliche hinaus mit Lymphödeme. Nicht nur die „Diagnose“ interessiert mich, sondern ebenso was für einen Effekt es hat auf unser Sozialleben und unser Selbstwertgefühl. Ich habe viel Zeit und Geld investiert in andere Länder zu reisen um alternativen kennenzulernen, ich war bei Internationale Firmen als Gast um zu sehen welche Lösungen geboten werden, habe fast jeden Lymphologischen Kongress besucht um mich weiter zu bilden und einige Projekte als Freelancer machen können. Wie ihr sieht ist das weitaus mehr als nur ein Blog, es müssen sich grundliegende Dinge verändern um uns alle das zu geben was wir verdienen, Respekt, Empathie und das Bewusstsein das wir nichts Vorübergehendes haben, sondern das dieses ein Teil unseres Lebens ist und auch bleibt. After being diagnosed with Cancer and going through treatments, Wertheim operation, radiation therapy and afterloading I was suddenly hit by Lymphedema. Totally surprising since nobody even gave me a hint that this could happen. Running from one doctor to the other trying to find out what is wrong with me and why my body was changing so quickly, once again being in the situation of not having control of anything. This made me so angry that I started studying like crazy, I wanted to find out why we are left alone, why doctors don’t have a clue (sorry, most doctors) about Lymphedema and the consequences in all aspects of our lives. Sadly, I had to realize that hardly anyone knows anything about it. I started my quest to find alternatives in treatments, I traveled around the world investing my time and money, fortunate enough to spend time in companies specialized in Lymphedema treatment to learn all that I could and can. I hardly miss any Lymphatic congress, listening to the internationally known doctors, discussing what is important for us as patients. I have done some freelance work for the companies that I believe in and had the chance to work with a wonderful company in New Jersey. I have tested alternatives and I am still searching and studying because it is my quest to change things for all affected by this, not only our physical wellbeing but most importantly the impact that it has on our daily life. It’s not something that’s going to go away, it’s with us until the end and the minimum that we can expect is being taken seriously, respect and empathy for our situation and the importance for all of us that have the possibilities to change things for the better. There is so much work to do, and I am not going to give up. As you can see this is more than a blog. If you find something interesting on Lymphfantastic but you are having problems with the German, then just send me a message and I will be happy to translate that for you, my native language is English so that is no problem. Have a great day and looking forward to hearing from you soon. Bless you all, Monica

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