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Die Suche geht weiter- The search goes on


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Intermittierende pneumatische Kompression und Kostensenkung/ Stanford University School of Medicine

Lymphedema home treatment improves outcomes, reduces costs, researchers find

DEC 3rd 2014

Home therapy helps control symptoms and save on the costs of treating lymphedema, a painful, often debilitating side effect of life-saving cancer treatments, a new study has found.

Patients with swelling caused by cancer-associated lymphedema can both reduce the severity of the disease and the overall cost of medical care by taking therapeutic steps at home, according to a study by researchers at the Stanford University School of Medicine.

The study looked at the prevalence of lymphedema, a common side effect of cancer treatments, and found that the average annual cost of care for a patient with the condition decreased from $62,190 to $50,000 a year when the patient used pneumatic compression devices to treat the swelling.

“Total health-care costs for these patients are very high, but can be profoundly reduced with treatment intervention, in this case a compression device,” said Stanley Rockson, MD, professor of cardiovascular medicine at Stanford and senior author of the study, published online Dec. 3 in PLOS ONE. “This is clearly a compelling argument for increased coverage of similar home-care devices to reduce costs.”

The first author of the study is Kimberly Brayton, MD, JD, a former cardiovascular fellow at Stanford.

Painful, debilitating fluid buildup

Lymphedema is most commonly caused by the removal of or damage to lymph nodes as a part of cancer treatment. It results from a blockage in the lymphatic system, which is part of the immune system. The blockage prevents lymph fluid from draining well, and the fluid buildup leads to swelling, which can be painful and debilitating. These symptoms can be controlled with various treatments, including treatments done at home and outpatient physical therapy. Home treatments for lymphedema include manual lymphatic massage, multilayer bandaging techniques and application of various compressive garments to reduce tissue fluid.

Researchers chose to examine the use of pneumatic compression devices as an example, primarily because it was an easy therapy method to track through health-insurance coding. “We chose one specific intervention, not because it should supersede the others, but just as a representative, readily identified treatment intervention,” Rockson said.

Pneumatic compression devices are inflatable garments that, when applied to the swollen area, inflate and deflate in cycles to help drain lymph-fluid buildup.

Lymphedema, which is incurable, is common among cancer survivors, although it’s unclear exactly how many people suffer from it. The disorder is often ignored and undertreated, said Rockson, who holds the Allan and Tina Neill Professorship in Lymphatic Research and Medicine.

For the study, researchers set out to determine both the prevalence of the disorder and the possible benefits of these home treatments by examining information collected from the health claims database of United Health Care Group/Optum, a private health insurer that operates in 24 states. Those figures were then used to extrapolate nationwide statistics. (The insurance company stripped patients’ personal information from the data used by the researchers.)

The researchers evaluated health care claims and other data collected by the insurer from 2007 to 2013. Results showed that in 2007, 9,025 of the 950,333 cancer patients in the insurance database were diagnosed with lymphedema — a prevalence of 0.95 percent. By 2013, 14,775 of the 1.19 million cancer patients were diagnosed with lymphedema — a prevalence of 1.2 percent.

Increasing rates of lymphedema

Researchers estimated the current number of cancer patients nationwide at 10 million. At a prevalence of 1.2 percent, that would mean about 121,000 lymphedema diagnoses nationwide.

“Cancer rates are expected to continue increasing at significant rates for the next 20 years,” Rockson said. “We can expect to see corresponding increasing rates of lymphedema.”

Researchers also examined health claims in the year prior to and the year following the initiation of  pneumatic compression therapy for lymphedema patients in the insurance company’s database. Results showed that annual costs of medical care decreased from $62,190 in the year prior to the use of the device to $50,000 in the year after they started using the device. During the year following the use of the devices, there was a reduction in the extent to which the patients used all categories of health care, including the frequency of treatment of soft tissue infection, the study said.

“The potential public health implications of these findings are substantial,” Rockson said. “As the American population ages and lymphedema rates increase, effective home therapies are likely to become increasingly important.”

Information about Stanford’s Department of Medicine, which supported the work, is available athttp://medicine.stanford.edu/.

Tracie White is a science writer for the medical school’s Office of Communication & Public Affairs. Email her at tracie.white@stanford.edu.
Stanley Rockson

Stanley Rockson found that home therapy could help reduce the severity of lymphedema, a common side effect of cancer treatment.
Norbert von der Groeben


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Professor Waldemar Lech Olszewski

Einen schönen guten Tag. Heute wollte ich mir die Zeit nehmen einen hervorragenden Wissenschaftler auf dem Gebiet der Lymphologie vorzustellen. Seine Passion, Wissen und Menschlichkeit bewegen mich sehr. Vielen Dank Prof. Olszewski !

Today I would like to take the time to introduce you to one of the best in the field of Lymphology . His name is Professor Waldemar Lech Olszewski. For me, a great comfort to know that his dedication and passion helps us all .  Thank-you Prof. Olszewski.

http://www.wlolszewski.com/

und /and

http://en.wikipedia.org/wiki/Waldemar_Olszewski


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Is the problem lymphoedema and its treatment or is it our knowledge?

 

Unglaublich, ich würde sofort um die Welt reisen um diesen Mann kennenzulernen , es muss doch langsam klar werden das alle gemeinsam arbeiten müssen damit etwas global bewegt werden kann. Hut ab Prof. Piller !

 

Editorial: Prof. Neil Piller , Neil Piller is Director Lymphoedema Research Unit, Department of Surgery, School of Medicine, Flinders University, Adelaide, South Australia, Australia.

 

Journal of Lymphoedema, 2014, Vol 9, No 1

Why do we struggle gaining recognition from patients and healthcare systems about the importance of the early detection of signs of lymphatic system failure, when we have tools available to do this? Why do we struggle getting funds for lymphoedema screening programmes, when we have strong indications they work? Why do we struggle with a serious lack of knowledge in the healthcare professional population when it comes to lymphoedema? Why do we see apparently contradictory outcomes reported in the literature in trials, systemic reviews and meta-analyses? Why don’t our healthcare systems seem to care ? So many questions. Maybe it’s us. Maybe its the words we use to describe lymphoedema as one form of chronic oedema. Maybe it’s the lack of — or relatively tight — funding available to undertake reasonably large clinical trials. Maybe we don’t collaborate closely enough, or maybe we just don’t know what to do and neither do the patients. Knowledge starts with education and, certainly, there is very little in medical courses focusing on lymphoedema. Vuong et al (2011) summarised findings from prior papers and discovered that about 50% of the Chairs in physiology departments at medical schools in the US indicated that 30 minutes or less are dedicated to lymphatics teaching with about 40% receiving 1–3 hours, while some only received 15 minutes. Incredibly, more than 60% thought this was sufficient! Furthermore, when lymphatic information was presented, it was only taught under the heading ‘lymphatic information’ 6% of the time. In the remaining 94% instances, it was presented in discussions relating to/as part of another of the bodily systems. So we have much to do in terms of enhancing knowledge then. How can we expect a GP or specialist to effectively deal with a patient presenting with lymphoedema with just this basic level of training? How can we ever expect them to gain an interest when they know so little about the lymphatic system and its disorders? There is significantly more information presented in the area of chronic oedema. Maybe, since lymphoedema is a form of chronic oedema, we could think about changing the term we use? However, on the negative side, we would then lose ‘lymphoedema’ as being associated with damage, malformation or destruction of the lymphatic system. We would also perhaps lose the ability to develop the area of lymphatics and lymphoedemas into a speciality area in the future. The origins of lymphoedema treatments (massage and compression) are many decades old and we are still discovering new things about the structure of the lymphatic system, with new imaging techniques, such as indocyanine green (Pan et al, 2008; 2013). Many treatments are undertaken based on information from trials that often were not conducted with as much control and rigour as they would be today. Trials often include a small sample size and can be heterogenous, leading, as could be expected, to differing or equivical outcomes that when read by practitioners, patients and healthcare system insurers are unlikely to instil confidence in many treatment or management strategies. Results from a recent trial, for example, showed no benefits from compression stockings for the prevention of lower-leg lymphedema after inguinal lymph node dissection (Stuiver et al, 2013), but perhaps the a priori criteria of effects were too high. As another example, a meta-analysis by Huang et al (2013) indicted little or no effect of even one of the mainstays of treatment — manual lymphatic drainage — while a systematic review and meta-analysis on pneumatic compression pumps for breast cancer-related lymphoedema showed that while intermittent pneumatic compression could alleviate lymphoedema, there was no significant difference between routine lymphoedema management with or without a pneumatic pump (Shao et al, 2014). So why this variation in outcomes and uncertainty about treatment? Many review authors indicate it is related to methodology issues and rigour but, more often, related to the study group size. The confusion and uncertainty can be unsettling, but must be dealt with. We can only do better for our patients by working together, combining resources and, therefore, having a stronger voice. I believe one step towards this can be made through our individual links to national and international groups, such as the International Lymphoedema Framework (ILF) and the International Society for Lymphology. At present, the ILF is working with its members and national frameworks to raise the profile of lymphoedema nationally and internationally, and to make lymphoedema a priority on national healthcare agendas. The ILF also aims to help clinicians lobby for appropriate funding or reimbursement for lymphoedema care; address inequality of provision issues; implement and evaluate lymphoedema services based on best practice; and create an international lymphedema community that collectively strives to improve the evidence base for treatment and professional practice.

References

Huang TW, Tseng SH, Lin CC et al (2013) Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials. World J Surg Oncol 11: 15

Pan WR, Suami H, Taylor GI (2008) Lymphatic drainage of the head and neck: anatomical study and clinical implications. Plast Reconst Surg 121(5): 1614–24

Pan WR, Wan D, Levy S, Chen Y (2013) Superficial lymphatic drainage of the lower extremity: anatomical study and clinical implications. Plast Reconst Surg 132(3): 696–707

Shao Y1, Qi K, Zhou QH, Zhong DS (2014) Intermittent pneumatic compression pump for breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials. Oncol Res Treat 37(4): 170–4

Stuiver M, de Rooij JD, Lucas C et al (2013) No evidence of benefit from class II compression stockings in the prevention of lower limb lymphoedema after inguinal lymph node dissection; Results of a randomised controlled trial. Lymphology 46(3): 120–31

Voung D, Nguyen M, Piller N (2011) Medical Education: A deficiency or disgrace? Journal of Lymphoedema 6(1): 44–9

Click to access content_11320.pdf


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A Biomechanical Approach to Lymphedema – Lymphatic Education & Research Network

Hello , this is very interesting. Please take the time to watch and listen. Have a great day.

 

http://new.livestream.com/LymphaticRF/JamesMoore/videos/68827859


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http://lymphaticnetwork.org/news-events/top-read-articles-on-lymphedema-from-lymphatic-research-and-biology


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Action Alert: Medicare Rules To Change For Pneumatic Compression Devices

Action Alert: Medicare Rules To Change For Pneumatic Compression Devices.

http://www.swr.de/landesschau-rp/offensive-gegen-kaum-erforschte-krankheit-das-lipoedem-shooting/-/id=122144/did=13571458/nid=122144/vi0c2h/index.html


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Lasers and night-vision technology help improve imaging of hidden lymphatic system

Lasers and night-vision technology help improve imaging of hidden lymphatic system

This is a typical near-infrared fluorescence image of lymphatics in the lower leg of a subject with lymphedema. Credit: John Rasmussen

The human lymphatic system is an important but poorly understood circulatory system consisting of tiny vessels spread throughout the body. This “drainage” network helps guard against infections and prevents swelling, which occasionally happens when disease or trauma interrupts normal lymphatic function. Chronic swelling is the hallmark of a painful, incurable condition known as lymphedema, which often occurs after cancer therapy and can leave the limbs and other body parts disfigured for life.

Detecting lymphedema early, before swelling occurs, would lead to better outcomes for patients, but the major barrier preventing early diagnosis is the lack of high-resolution imaging techniques that can resolve these tiny vessels. Recently, a team of researchers at The University of Texas Health Science Center at Houston (UTHealth) Medical School has developed a new technology that can non-invasively image the human  (also known as “lymphatics”). A fluorescent dye and commercially-available laser diode and military-grade night vision devices are used to visualize the lymphatic capillaries.

Clinically, the device promises dramatic improvements in patient care because it allows even tiny  to be imaged, and it can quantitatively measure fluid flow throughout the lymphatic system—two types of measurements that are impossible with today’s technology.

At CLEO: 2014, being held June 8-13 in San Jose, California, USA, UTHealth scientist John Rasmussen will describe how they have taken this technology, which they call near-infrared fluorescence lymphatic imaging (NIRFLI), from bench-top development to various clinical applications.

“We feel that the ability to see the lymphatics will provide opportunities to revolutionize lymphatic care,” Rasmussen said.

Lasers and night-vision technology help improve imaging of hidden lymphatic system

This is a typical near-infrared fluorescence image of healthy lymphatics in the lower arm. Credit: John Rasmussen

Why the Human Lymphatic System is Hard to Image

The major problem with lymphatic imaging is that the small  are filled with lymph, a clear liquid that lacks the natural contrast needed to show up on instruments like CT scanners or MRIs. While one might think about injecting dyes or other contrast “agents” into the lymphatic vessels to make them more visible, the vessels are very difficult to find and are most often too small to insert a needle.

An existing technology, called lymphoscintigraphy, can take images of the lymphatic system following injection of a radioactive compound into or below the skin. However, lymphoscintigraphy typically takes 20-45 minutes to acquire a single grainy picture, and can only image the largest lymphatic vessels or trunks. The smaller vessels, which make up the bulk of the lymphatic system, are invisible to lymphoscintigraphy. In addition because of the long acquisition times, it cannot capture the real-time flow of fluid in the system.

To acquire images of the lymphatics, NIRFLI uses indocyanine green dye, which is injected in tiny amounts into the skin of a patient. The dye is absorbed into the lymphatics and when illuminated by the laser diode, it emits a fluorescent light, which the device amplifies with a military-grade image intensifier—the main component in night vision goggles—and then captures with a commercial CCD digital camera.

The image intensifier enables the small lymphatic vessels to be visualized, and by taking sequences of such images, they can produce movies showing flow within the lymphatics. Rasmussen said that the most immediate promise of NIRFLI will be to diagnose and monitor the treatment of lymphedema and may also help surgeons identify and remove lymph nodes into which cancer tumors drain.

“From these images and movies, we can identify abnormal lymphatic structure and function in a variety of diseases and disorders in which the lymphatics play a role,” Rasmussen said. “I think we have barely scratched the surface of what is possible.”

 

More information: Presentation AM1P.1, titled “Clinical Translation and Discovery with Near-infrared Fluorescence Lymphatic Imaging,” will take place Monday, June 9, at 8 a.m. in the Willow Glen I – III Room of the San Jose Marriott.

Read more at: http://phys.org/news/2014-06-lasers-night-vision-technology-imaging-hidden.html#jCp

 

 

 

 


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Neue funktion für einen botenstoff – das wäre doch genial

 

http://www.medstand.com/neue-funktion-fur-einen-botenstoff  

ETH Zürich Assistent Professor Cornelia Halin und ihre Kollegen haben eine neue Funktion des bekannten Messenger-Protein Interleukin-7 entdeckt: es erleichtert den Abfluss von Lymphflüssigkeit aus dem Gewebe. In Zukunft wollen die Wissenschaftler untersuchen, ob dieses Molekül verwendet werden könnten, zu verhindern oder zu behandeln Lymphödem werden.

Das Molekül Interleukin-7 (IL-7) ist ein wichtiger Immunbotenstoff Protein, das eine ausreichende Zahl von T-Zellen vorhanden sind, im Körper für die Immunabwehr gewährleistet. Forscher der ETH Zürich haben nun gezeigt, dass IL-7 eine weitere wichtige Funktion hat: es verbessert die Funktion der Entwässerung Lymphgefäßen, die Flüssigkeit zu sammeln, die von Blutgefäßen in das Körpergewebe durchgesickert und senden es an die Blutbahn. In Zukunft könnte diese Erkenntnis nützlich werden für Lymphödem-Patienten, deren Lymphdrainage nicht richtig funktioniert, was in Flüssigkeitsansammlung und Gewebe Schwellung.
Die Veranlagung zu Lymphödem entwickeln kann, einerseits erblich bedingt sein. Auf der anderen Seite, Lymphödem tritt häufig in der Zeit nach einer Tumor-Chirurgie. Bei primären Tumoren chirurgisch herausgeschnitten werden Tumor-Lymphknoten oft als gut, entfernt, da sie möglicherweise Tumorzelle Metastasen enthalten. Im Verlauf eines solchen chirurgischen Eingriffen wird das lymphatische Gewebe beschädigt. Als Ergebnis kann Gewebeflüssigkeit oft nicht mehr ordnungsgemäß entleert werden, was zum Auftreten von lymphedema in 20 bis 30 Prozent der Patienten.
Keine medikamentöse Behandlung noch
Derzeit sind die einzigen Behandlungsoptionen für Lymphödem-Patienten tragen Kompressionsstrümpfe und unterziehen manuelle Lymphdrainage durch einen medizinischen Masseur.”In IL-7, wir haben ein Molekül und einen Mechanismus für die Verbesserung der Lymphdrainage, die möglicherweise sein könnte für Lymphödem-Therapie nützlich entdeckt”, sagt der Leiter der Studie Cornelia Halin, Assistant Professor of Drug Discovery Technologies.
In ihrer Studie fanden die Forscher, dass IL-7 durch die sogenannte Endothelzellen, die das lymphatische Behälterwand bilden erzeugt wird. Diese Zellen exprimieren auch die Rezeptoren, die spezifisch IL-7 basiert auf dem Schloss-und-Schlüssel-Prinzip. “Obwohl wir nicht formal bewiesen haben, so weit gehen wir davon aus, dass die lymphatischen Endothelzellen den Botenstoff produzieren, so dass sie ihre eigene Funktion direkt beeinflussen können”, sagt Halin. Bisher ist IL-7 eine von nur wenigen Molekülen, die identifiziert wurden, um Lymphdrainage unterstützt. Vor ein paar Jahren entdeckten Forscher, dass die anderen endogenen Wachstumsfaktor VEGF-C könnte auch ein interessantes Molekül in dieser Hinsicht sein.

Erkenntnisse aus einem Tiermodell
Halin und Kollegen gezeigt, die Drainage-tragende Funktion von IL-7, indem Drainage Experimente in Mäusen injiziert, wo sie eine blaue, Albumin-bindenden Farbstoff in das Ohr Haut der Mäuse. Bemerkenswert ist, dass Albumin ein endogenes Protein, das kann nur von dem Gewebe transportiert werden über die Lymphgefäße. Durch die Quantifizierung der Farbstoff, der in dem Gewebe einen Tag nach der Injektion blieb, waren die Forscher in der Lage, festzustellen, wie gut die Lymphdrainage in diesen Versuchstieren gearbeitet.
Bei der Durchführung dieses Experiment bei Mäusen fehlt ein funktionierendes IL-7 Rezeptors, beobachteten sie, dass diese Mäuse konnten nur halb so viel Farbstoff aus ihrer Haut zu entfernen Ohr im Vergleich zu Mäusen mit einem funktionierenden IL-7-Rezeptor.Im Gegensatz dazu stellten sie eine deutliche Steigerung der lymphatische Drainage in Mäusen mit erhöhter IL-7-Produktion. Schließlich wird in einem dritten Experiment sie IL-7 Proteins, modifizierten, gesunde Mäuse verabreicht und beobachtet, dass diese therapeutischen Behandlung zur Verbesserung Lymphabstrombereich Funktion geführt.
Bereits bei Patienten getestet
Die Wissenschaftler planen nun, ähnliche Experimente in Mäusen, in denen Lymphgefäße chirurgisch zerstört durchzuführen, ähnlich der Situation bei Patienten nach einer Krebsoperation gefunden. Hier würden die Forscher gerne testen, ob die Behandlung mit IL-7 könnte helfen, Lymphödem oder ob IL-7 könnte sogar verabreicht, um bestehenden Lymphödem reduzieren verhindern.
Das langfristige Ziel ist es, das Potenzial eines IL-7-basierte Medikamente für Lymphödem zu erkunden. Bemerkenswert ist, dass IL-7 bereits in klinischen Studien getestet, wenn auch für verschiedene Indikationen: wegen seiner immun-stimulierende Aktivität auf T-Zellen, IL-7 wird derzeit bei Patienten mit Immunschwäche Krankheiten wie HIV oder Hepatitis-Infektionen getestet, haben oder die Knochenmark-Transplantationen unterzogen.

 

 

Science

New function for a messenger molecule

ETH Zurich Assistant Professor Cornelia Halin and her colleagues have discovered a new function of the well-known messenger protein interleukin-7: it facilitates the drainage of lymph fluid from tissues. In the future, the scientists plan to investigate whether this molecule could be used to prevent or treat lymphedema.

Fabio Bergamin

ETH scientists have studied the drainage function of lymphatic vessels. This picture shows a close-up view of a mouse ear. The blue substance is an injected dye that is absorbed and drained by lymphatic vessels. The red structures are blood vessels. (Photo: David Aebischer / ETH Zurich)

ETH scientists have studied the drainage function of lymphatic vessels. This picture shows a close-up view of a mouse ear. The blue substance is an injected dye that is absorbed and drained by lymphatic vessels. The red structures are blood vessels. (Photo: David Aebischer / ETH Zurich) (large view)

The molecule interleukin-7 (IL-7) is an important immune messenger protein which ensures that a sufficient number of T cells are present in our body for immune defence. Researchers from ETH Zurich have now demonstrated that IL-7 has another important function: it enhances the drainage function of lymphatic vessels, which collect fluid that has leaked out of blood vessels into the body tissue and return it to the bloodstream. In the future, this finding could become useful for lymphedema patients, whose lymphatic drainage system does not work properly, resulting in fluid accumulation and tissue swelling.

The predisposition to develop lymphedema may, on one hand, be hereditary. On the other hand, lymphedema often occurs in the aftermath of a tumour surgery. When primary tumours are surgically excised, tumour-draining lymph nodes are often removed as well, as they may contain tumour cell metastases. In the course of such surgical interventions, the lymphatic tissue is damaged. As a result, tissue fluid can often no longer be drained properly, leading to the occurrence of lymphedema in 20 to 30 per cent of patients.

No drug treatment yet

Currently, the only treatment options for lymphedema patients are wearing compression garments and undergoing manual lymph drainage by a medical massage therapist. “In IL-7, we have discovered a molecule and a mechanism for enhancing lymphatic drainage which could potentially be useful for lymphedema therapy,” says the head of the study Cornelia Halin, Assistant Professor of Drug Discovery Technologies.

In their study, the researchers found that IL-7 is produced by the so-called endothelial cells, which form the lymphatic vessel wall. These cells also express the receptors that specifically recognise IL-7 based on the lock-and-key principle. “Although we have not formally proven it so far, we assume that the lymphatic endothelial cells produce the messenger substance so that it can affect their own function directly,” says Halin. So far, IL-7 is one out of only few molecules that have been identified to support lymphatic drainage. A few years ago, other researchers discovered that the endogenous growth factor VEGF-C might also be an interesting molecule in this regard.

Insights from an animal model

Halin and her colleagues demonstrated the drainage-supporting function of IL-7 by performing drainage experiments in mice where they injected a blue, albumin-binding dye into the ear skin of the mice. Notably, albumin is an endogenous protein, which can only be transported out of the tissue via the lymphatic vessels. By quantifying the dye that remained in the tissue one day after the injection, the researchers were able to determine how well the lymphatic drainage worked in these laboratory animals.

When performing this experiment in mice lacking a functioning IL-7 receptor, they observed that these mice were only able to remove half as much dye from their ear skin in comparison with mice possessing a functional IL-7 receptor. By contrast, they observed a considerable increase in lymphatic drainage in mice with increased IL-7 production. Finally, in a third experiment, they administered IL-7 protein to unmodified, healthy mice and observed that this therapeutic treatment led to an improvement of lymphatic drainage function.

Already tested in patients

The scientists are now planning to conduct similar experiments in mice in which lymphatic vessels have been surgically destroyed, similarly to the situation found in patients after cancer surgery. Here, the researchers would like to test whether treatment with IL-7 could help to prevent lymphedema or whether IL-7 could even be administered in order to reduce existing lymphedema.

The long-term goal is to explore the potential of an IL-7-based medication for lymphedema. Notably, IL-7 is already being tested in clinical trials, albeit for different indications: because of its immune-stimulatory activity on T cells, IL-7 is currently being tested in patients with immunodeficiency diseases, such as HIV, or hepatitis infections, or who have undergone bone-marrow transplantations.

Literature reference

Iolyeva M, Aebischer D et al.: Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood, 2013, published ahead of print, doi: 10.1182/blood-2013-01-478073